Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model.Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical

Organ/tissue transplantation has become an effective therapy for end-stage diseases.However, immunosuppression after transplantation may cause severe side effects.Donor-specific transplant tolerance was proposed to solve this problem.In this study, we report a novel method for inducing and maintaining heart allograft tolerance rats.First, we induce

The present article is the result of comparative studies devoted to some pre-selected versions of the Bible with a focus on pragmatics and semantics.The conducted research was guided by the following assumption: the meaning of Biblical texts is directly related to pragmatism but despite similarities and differences between the analyzed versions of

Antiviral drug development has been slow due CELERY SEED EXTRACT to many factors.One such factor is the difficulty to block the viral replication in the cell without adversely affecting the host cell metabolic activity.Most of the antiviral compounds are analogs of purines and pyramidines.Currently available antiviral drugs mainly inhibit viral Adu